CHANGES IN THE CONCENTRATIONS OF ETHANOL, METHANOL AND METABOLITES OFSEROTONIN IN 2 SUCCESSIVE URINARY VOIDS FROM DRINKING DRIVERS

Citation
Aw. Jones et A. Helander, CHANGES IN THE CONCENTRATIONS OF ETHANOL, METHANOL AND METABOLITES OFSEROTONIN IN 2 SUCCESSIVE URINARY VOIDS FROM DRINKING DRIVERS, Forensic science international, 93(2-3), 1998, pp. 127-134
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, Legal
ISSN journal
0379-0738
Volume
93
Issue
2-3
Year of publication
1998
Pages
127 - 134
Database
ISI
SICI code
0379-0738(1998)93:2-3<127:CITCOE>2.0.ZU;2-R
Abstract
The urine-ethanol concentration (UEC), the urine-methanol concentratio n (UMC) and the ratio of serotonin metabolites, 5-hydroxytryptophol (5 HTOL) to 5-hydroxyindoleacetic acid (5HIAA), were determined in two su ccessive voids from apprehended drunk drivers (n=35). The blood-ethano l concentration (BEC) ranged from 0-3.00 g/l (mean 1.87 g/l, median 2. 03 gill compared with 0-3.96 g/l (mean 2.48 g/l, median 2.73 g/l) in t he first urinary void and 0-3.56 g/l (mean 2.24 g/l, median 2.47 g/l) in the second void. The UEC decreased significantly from 2.48+/-0.99 g /l to 2.24+/-0.95 g/l (mean+/-S.D.) between first and second voids as did the UEC/BEC ratios, changing from 1.33 +/- 0.15 to 1.20 +/- 0.10, The BEC and UEC were highly correlated; r=0.97+/-0.04 (p<0.001) for th e first void and r = 0.98 +/- 0.03 (p<0.001) for the second void. The UMC increased from 7.51 +/- 4.95 mg/l to 8.01 +/- 5.03 mg/l between th e first and second Voids and the mean difference of 0,50 +/- 0.78 mg/l was statistically highly significant (p<0.001). The ratios of 5HTOL/5 HIAA were 771 +/- 363 pmol/nmol and 728 +/- 377 pmol/nmol in first and second voids, respectively and the difference was not statistically s ignificant (p>0.05). Finding raised concentrations of methanal and a h igh 5HTOL/5HIAA ratio in urine specimens provides additional evidence to confirm recent drinking. These biochemical markers might prove usef ul whenever the integrity of blood or urine specimens is questioned, f or example, owing to contamination with extraneous ethanol during coll ection or microbial synthesis of ethanol in vitro after sampling. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.