MUTATION SPECTRA OF COMPLEX-MIXTURES

Authors
Citation
Dm. Demarini, MUTATION SPECTRA OF COMPLEX-MIXTURES, Mutation research. Reviews in mutation research, 411(1), 1998, pp. 11-18
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Genetics & Heredity",Toxicology,"Biothechnology & Applied Migrobiology
ISSN journal
1383-5742
Volume
411
Issue
1
Year of publication
1998
Pages
11 - 18
Database
ISI
SICI code
1383-5742(1998)411:1<11:MSOC>2.0.ZU;2-7
Abstract
Mutation spectra of complex mixtures or simple binary mixtures have be en determined thus far only in Salmonella. This review summarizes thes e studies, which have involved a variety of complex mixtures, chemical fractions of the mixtures, and single compounds that are representati ve of the primary chemical classes within the mixtures. For the partic ulate organics from urban air and municipal waste incinerator emission s, cigarette smoke condensate, and organic extracts of chlorinated dri nking water, the mutation spectrum of the mixture reflected the domina nce of one or a few chemical classes within the mixture. The mutation spectra of sunlight and cigarette smoke in Salmonella were similar to those found in the p53 gene of skin or lung tumors in people associate d with exposure to these two mutagens. These data provide possible mec hanistic links between the types of mutations induced by complex envir onmental mutagens in an experimental organism (Salmonella) and the typ es of mutations found in humans exposed to the same environmental muta gens. The primary class of mutation produced by many mutagens within a chemical class (and even among different classes) is frequently the s ame. These studies indicate that, to some extent, complex mixture-indu ced mutation spectra can be modeled by the predominant mutagenic chemi cal class in that mixture and even by a single model compound in that chemical class. Such information should be useful in the interpretatio n of mutation spectra in molecular epidemiological studies where the e xposure is primarily to a complex mixture. (C) 1998 Elsevier Science B .V. All rights reserved.