ROLE OF DIGITALIS-LIKE SUBSTANCE IN THE HYPERTENSION OF STREPTOZOTOCIN-INDUCED DIABETES AND SIMULATED WEIGHTLESSNESS IN RATS

Citation
Mb. Pamnani et al., ROLE OF DIGITALIS-LIKE SUBSTANCE IN THE HYPERTENSION OF STREPTOZOTOCIN-INDUCED DIABETES AND SIMULATED WEIGHTLESSNESS IN RATS, Clinical and experimental hypertension, 20(5-6), 1998, pp. 509-521
Citations number
47
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Peripheal Vascular Diseas
ISSN journal
1064-1963
Volume
20
Issue
5-6
Year of publication
1998
Pages
509 - 521
Database
ISI
SICI code
1064-1963(1998)20:5-6<509:RODSIT>2.0.ZU;2-U
Abstract
We have examined the role of plasma Na+-K+ pump inhibitor (SPI) in the hypertension of streptozotocin induced insulin dependent diabetes (ID DM) in reduced renal mass rats. The increase in blood pressure (BP) wa s associated with an increase in extracellular fluid volume (ECFV), an d SPI and a decrease in myocardial Na+,K(+)ATPase (NKA) activity, sugg esting that increased SPI, which inhibits cardiovascular muscle (CVM) cell NKA activity, may be Involved in the mechanism of IDDM-hypertensi on. In a second study, using prolonged suspension resulted in a decrea se in cardiac NKA activity, suggesting that cardiovascular decondition ing following space flight might in part result from insufficient SPI.