INCREASED RELEASE OF NITRIC-OXIDE IN ISCHEMIC HEARTS AFTER EXERCISE IN PATIENTS WITH EFFORT ANGINA

Citation
K. Node et al., INCREASED RELEASE OF NITRIC-OXIDE IN ISCHEMIC HEARTS AFTER EXERCISE IN PATIENTS WITH EFFORT ANGINA, Journal of the American College of Cardiology, 32(1), 1998, pp. 63-68
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiac & Cardiovascular System
ISSN journal
0735-1097
Volume
32
Issue
1
Year of publication
1998
Pages
63 - 68
Database
ISI
SICI code
0735-1097(1998)32:1<63:IRONII>2.0.ZU;2-0
Abstract
Objectives. The aim of this study was to determine whether the release of nitric oxide (NO) from the ischemic heart increases during exercis e in patients with effort angina. Background. Myocardial ischemia incr eases NO production in the canine heart, but no such increase has been demonstrated in the ischemic human heart. Methods. Fifteen patients w ith effort angina underwent supine ergometer exercise tests. All patie nts had severe proximal stenosis (>90%) in the left anterior descendin g coronary artery. The control group consisted of 17 subjects without coronary artery disease or systemic hemodynamic abnormalities. Results . Neither the lactate extraction ratio (LER) nor the difference in NO concentration between coronary venous and arterial blood (Delta VA[NO] ) was affected by exercise in the control subjects. In patients with e ffort angina, neither variable differed from that in the control group at rest; however, exercise markedly decreased LER and significantly i ncreased Delta VA(NO) (from 4.7 +/- 0.3 to 16.5 +/- 1.6 mu mol/liter, p < 0.001) in the patient group. The extent of decrease in LER was sig nificantly correlated with the extent of increase in Delta VA(NO) in t he patients with effort angina (r(2) = -0.837, p < 0.001). Conclusions . Provocation of myocardial ischemia by exercise stress increases NO p roduction in the hearts of patients with effort angina. (C) 1998 by th e American College of Cardiology.