CHANGES IN THE GASTRIC VASCULAR NETWORK OF MALIGNANT STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (M-SHRSP) AFTER ADMINISTRATION OF THE CALCIUM-ANTAGONIST MANIDIPINE

Citation
A. Chiba et al., CHANGES IN THE GASTRIC VASCULAR NETWORK OF MALIGNANT STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (M-SHRSP) AFTER ADMINISTRATION OF THE CALCIUM-ANTAGONIST MANIDIPINE, Research communications in molecular pathology and pharmacology, 100(2), 1998, pp. 151-160
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
ISSN journal
1078-0297
Volume
100
Issue
2
Year of publication
1998
Pages
151 - 160
Database
ISI
SICI code
1078-0297(1998)100:2<151:CITGVN>2.0.ZU;2-M
Abstract
In malignant SHRSP (M-SHRSP), a strain of stroke-prone spontaneously h ypertensive rat (SHRSP), blood pressure rapidly increases during early development (5 weeks of age). Changes in the gastric vascular archite cture of WKY and M-SHRSP were investigated using scanning electron mic roscope images of vascular casts focusing on the morphological differe nces in the three-dimensional arrangement of the capillaries. In WKY, the density, tortuosity and regular honeycomb formation of the gastric vessels were studied. The casts of gastric capillaries were 5.9 +/- 0 .6 mu m in diameter with a regular smooth surface. In M-SHRSP, the ove rall vascular pattern was not regularly organized at 6.3 +/- 1.9 mu m in capillary diameter. Administration of the Ca antagonist, manidipine , to 11-week-old M-SHRSP with hypertensive vascular lesions decreased blood pressure and prolonged the rats' survival. With the administrati on of manidipine, vascular morphological patterns became similar to th at of normotensive WKY, and the mean capillary diameter was 8.4 +/- 1. 2 mu m. It seems that manidipine plays a role in the recovery of norma l vascular structure, as well as decreasing blood pressure.