TRANSFORMING-GROWTH-FACTOR-BETA IN RENAL-DISEASE

Citation
M. Bitzer et al., TRANSFORMING-GROWTH-FACTOR-BETA IN RENAL-DISEASE, Kidney & blood pressure research, 21(1), 1998, pp. 1-12
Citations number
136
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Peripheal Vascular Diseas","Urology & Nephrology",Physiology
ISSN journal
1420-4096
Volume
21
Issue
1
Year of publication
1998
Pages
1 - 12
Database
ISI
SICI code
1420-4096(1998)21:1<1:TIR>2.0.ZU;2-W
Abstract
An extensive number of animal and clinical studies indicate that trans forming growth factors-beta (TGF-beta s)play an important role in infl ammatory and fibrotic diseases, including renal fibrosis. Recent mouse models harboring genetically engineered alterations in TGF-P pathways reveal complicated mechanisms of regulation of TGF-beta activity in v ivo. The purpose of this review is to present recent advances relevant to our understanding of the TGF-beta-signaling system in renal physio logy and pathophysiology.