SECRETION OF INTERLEUKIN-2 FROM UNSTIMULATED PERIPHERAL-BLOOD MONONUCLEAR-CELLS IS A POSSIBLE PATHOGENIC MECHANISM IN RECURRENT ABORTION

Citation
Y. Hamai et al., SECRETION OF INTERLEUKIN-2 FROM UNSTIMULATED PERIPHERAL-BLOOD MONONUCLEAR-CELLS IS A POSSIBLE PATHOGENIC MECHANISM IN RECURRENT ABORTION, AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 40(1), 1998, pp. 63-64
Citations number
4
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Biology",Immunology
ISSN journal
1046-7408
Volume
40
Issue
1
Year of publication
1998
Pages
63 - 64
Database
ISI
SICI code
1046-7408(1998)40:1<63:SOIFUP>2.0.ZU;2-2
Abstract
PROBLEM: The objective of this study was to evaluate the activated sta tus of helper T cells in women with recurrent abortion. METHOD OF STUD Y: The spontaneous secretion of interleukin (IL)-2 from peripheral blo od mononuclear cells (PBMCs) obtained from 12 women with primary partn er-specific recurrent abortion and 7 normal females and 10 normal male s was measured. RESULTS: IL-2 concentrations in medium conditioned wit h PBMCs from the recurrent abortion group were 1.44 +/- 0.32 (mean +/- standard deviation) U/ml, whereas those from the normal female and ma le groups were below the minimum detectable concentration. CONCLUSION: The fact that PBMCs from recurrent aborters spontaneously secrete IL- 2 suggests that helper T cells are activated in recurrent aborters.