THE INFLUENCE OF REPRODUCTIVE AND HORMONAL FACTORS ON THE RISK OF COLON AND RECTAL-CANCER IN WOMEN

Citation
R. Talamini et al., THE INFLUENCE OF REPRODUCTIVE AND HORMONAL FACTORS ON THE RISK OF COLON AND RECTAL-CANCER IN WOMEN, European journal of cancer, 34(7), 1998, pp. 1070-1076
Citations number
51
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ISSN journal
0959-8049
Volume
34
Issue
7
Year of publication
1998
Pages
1070 - 1076
Database
ISI
SICI code
0959-8049(1998)34:7<1070:TIORAH>2.0.ZU;2-5
Abstract
A case-control study was conducted between 1992 and 1996 in six Italia n areas. It included 537 women with colon cancer, 291 women with recta l cancer and 2081 control women in hospital for acute conditions, unre lated to hormonal or gynaecological diseases. A higher age at menopaus e was associated with increased colon cancer risk (odds ratio (OR) for greater than or equal to 53 years compared with < 50 years = 1.39, 95 % confidence interval (CI) 1.04-1.87), Among parous women, a significa nt trend of decreasing colon cancer risk with increasing number of bir ths was seen for colon (OR for greater than or equal to 4 births compa red with 1 birth = 0.62, 95% CI 0.42-0.90), but not for rectal cancer. Nulliparous women, however, were at lower risk than women with a sing le birth, and age at first birth was directly associated with risk. Wh ile oral contraceptive use showed no significant influence, ever users of hormone replacement therapy had a reduced risk of rectal cancer (O R = 0.56, 95% CI 0.31-1.01). Thus, the association of colorectal cance r with reproductive and menstrual factors is neither strong nor consis tent. (C) 1998 Elsevier Science Ltd. All rights reserved.