A NEURAL RESPONSE WITH 3-MS LATENCY EVOKED BY LOUD SOUND IN PROFOUNDLY DEAF PATIENTS

Citation
T. Kato et al., A NEURAL RESPONSE WITH 3-MS LATENCY EVOKED BY LOUD SOUND IN PROFOUNDLY DEAF PATIENTS, Audiology & neuro-otology, 3(4), 1998, pp. 253-264
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Otorhinolaryngology,Neurosciences
Journal title
ISSN journal
1420-3030
Volume
3
Issue
4
Year of publication
1998
Pages
253 - 264
Database
ISI
SICI code
1420-3030(1998)3:4<253:ANRW3L>2.0.ZU;2-2
Abstract
A large negative deflection with a latency of 3 ms was observed in the auditory brainstem response (ABR) waveforms of some patients with per ipheral profound deafness, This deflection was termed the N3 potential . In this paper, we review patients with the N3 potential and discuss the characteristics of abnormal ABR waveforms, The origin of the N3 po tential was also discussed, especially with respect to vestibular evok ed potentials, In most of the patients, audiograms showed no response to the maximum output of an audiometer in the high-frequency range and a residual response in the low-frequency range, The N3 potentials wer e noted at intensities of 80 dB nHL or greater, As the stimulus intens ity increased, the amplitude of the potential increased and the latenc y decreased, A high repetition rate (83.3/s) of the click stimulus inf luenced the latency and amplitude of the N3 potential, The potential w as replicated on retest within less than a month, and had a consistent latency and amplitude over the scalp, The results indicate that the N 3 potential is not an electrical artifact but a physiological neural r esponse evoked by a loud sound, The N3 potential is most likely not an auditory evoked response from cochlear or a response from a semicircu lar canal, because it has a 3-ms latency, a sharp waveform, and is una ssociated with vertigo, The results suggest that the N3 potential may be a saccular acoustic response.