WHOLE GRAIN FOOD-INTAKE AND CANCER RISK

Citation
L. Chatenoud et al., WHOLE GRAIN FOOD-INTAKE AND CANCER RISK, International journal of cancer, 77(1), 1998, pp. 24-28
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0020-7136
Volume
77
Issue
1
Year of publication
1998
Pages
24 - 28
Database
ISI
SICI code
0020-7136(1998)77:1<24:WGFACR>2.0.ZU;2-G
Abstract
The relationship between frequency of consumption of whole grain food and risk of selected neoplasms has been analysed using data from an in tegrated series of case-control studies conducted in northern Italy be tween 1983 and 1996. The overall dataset included the following incide nt, histologically confirmed neoplasms: oral cavity and pharynx 181, o esophagus 316, stomach 745, colon 828, rectum 498, liver 428, gallblad der 60, pancreas 362, larynx 242, breast 3,412, endometrium 750, ovary 971, prostate 127, bladder 431, kidney 190, thyroid 208, Hodgkin's di sease 80, non-Hodgkin's lymphomas 200, multiple myelomas 120. Controls were 7,990 patients admitted to hospital for acute, non-neoplastic co nditions, unrelated to long-term modifications in diet and neat likely to have been caused by tobacco or alcohol use. Odds ratios (OR) for s ubsequent scores (never/occasional/ frequent) of whole grain food cons umption were derived after allowance for age, sex, education, smoking, alcohol intake and body mass index. High intake of whole grain foods consistently reduced risk of neoplasm at:all sites, except thyroid. Th e ORs for the highest category of consumption were 0.2-0.3 for upper d igestive and respiratory tract neoplasms, 0.5 for stomach, colon and g allbladder, 0.7 for rectum, 0.6 for liver, 0.8 for pancreas and prosta te, 0.9 for breast and endometrium, 0.6 for ovary, 0.4 for bladder and kidney, 1.3 for thyroid and around 0.5 for lymphomas and myeloma. The rests for trend in risks were significant for all neoplasms, except p ancreas, endometrium, Hodgkin's disease and multiple myeloma. No signi ficant heterogeneity was found across strata of age at diagnosis, sex, education, smoking habit, alcohol intake and body mass index. Thus, e ven in the absence of a univocal and satisfactory biological interpret ation, the consistency of the patterns observed indicate that, in this population, higher frequency of whole grain food intake is an indicat or of reduced risk of several neoplasms, (C) 1998 Wiley-Liss, Inc.