INHIBITION OF NF-KAPPA-B-DEPENDENT TRANSCRIPTION OF HUMAN-IMMUNODEFICIENCY-VIRUS-1 PROMOTER BY A PHOSPHODIESTER COMPOUND OF VITAMIN-C AND VITAMIN-E, EPC-K1

Citation
F. Hirano et al., INHIBITION OF NF-KAPPA-B-DEPENDENT TRANSCRIPTION OF HUMAN-IMMUNODEFICIENCY-VIRUS-1 PROMOTER BY A PHOSPHODIESTER COMPOUND OF VITAMIN-C AND VITAMIN-E, EPC-K1, Immunopharmacology, 39(1), 1998, pp. 31-38
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
ISSN journal
0162-3109
Volume
39
Issue
1
Year of publication
1998
Pages
31 - 38
Database
ISI
SICI code
0162-3109(1998)39:1<31:IONTOH>2.0.ZU;2-E
Abstract
We investigated the effect of EPC-K1, which is a phosphodiester compou nd of vitamin E and vitamin C, on NF-kappa B activity in human culture d astrocytoma cells T98G. In TNF alpha-stimulated T98G cells, treatmen t with EPC-K1 inhibited both DNA binding activity and transactivation of NF-kappa B in a dose-dependent manner, and the suppressive effect o f EPC-K1 was stronger than either that of vitamin E or vitamin C. More over, we showed that in TNF alpha-stimulated T98G cells treatment with EPC-K1 repressed NF-kappa B-dependent activation of the human immunod eficiency virus 1 promoter. In contrast, TNF alpha-induced activation of the human immunodeficiency virus 1 promoter was not completely inhi bited by either treatment with vitamin E or vitamin C. We, thus, sugge st that EPC-K1 is considered to be one of the inhibitory agents of NF- kappa B. (C) 1998 Elsevier Science B.V.