GROWTH HORMONE-BINDING PROTEIN DIRECTLY DEPENDS ON SERUM LEPTIN LEVELS IN ADULTS WITH DIFFERENT NUTRITIONAL-STATUS

LLOPIS MA GRANADA ML CUATRECASAS G FORMIGUERA X SANCHEZPLANELL L SANMARTI A ALASTRUE A RULL M COROMINAS A FOZ M

Ma. Llopis et al., GROWTH HORMONE-BINDING PROTEIN DIRECTLY DEPENDS ON SERUM LEPTIN LEVELS IN ADULTS WITH DIFFERENT NUTRITIONAL-STATUS, The Journal of clinical endocrinology and metabolism, 83(6), 1998, pp. 2006-2011

42

INGLESE

Article

Endocrynology & Metabolism

The Journal of clinical endocrinology and metabolism → ACNP

0021-972X

83

6

1998

2006 - 2011

ISI

0021-972X(1998)83:6<2006:GHPDDO>2.0.ZU;2-M

The aim of this work was to assess the relationship between GH-binding protein (GHBP) and leptin. Both peptides are nutritionally regulated, but the recent implication of a role for leptin in the GH axis requir es further study. To avoid the sexual dimorphism in leptin values, we performed leptin standardization according to gender (SD score-leptin) . The relationship between so score-leptin and GHBP was studied in 128 adults with different nutritional status [8 groups according to body mass index (BMI)], ranging from severely underweight anorexia nervosa to highly morbid obesity. Both GHBP and SD score-leptin significantly increase according to BMI within the range from 18-27 kg/m(2), whereas no significant differences were found among underweight groups (BMI, <18 kg/m(2)) or among obesity grades (BMI, >27 kg/m(2)). We found a st rong correlation between GHBP and SD score-leptin (r = 0.8; P < 0.0001 ). Multiple regression analysis revealed so score-leptin to be a signi ficant determinant of GHBP, accounting for 64% of the variation, where as BMI did not contribute further to explaining changes in GHBP. This suggests a physiological pathway involving both GHBP (the soluble frac tion of GH receptor) and leptin. Thus, we might speculate that leptin could be the signal that induces the related nutritional changes obser ved in GHBP/GH receptor expression.