GROWTH HORMONE-BINDING PROTEIN DIRECTLY DEPENDS ON SERUM LEPTIN LEVELS IN ADULTS WITH DIFFERENT NUTRITIONAL-STATUS

Citation
Ma. Llopis et al., GROWTH HORMONE-BINDING PROTEIN DIRECTLY DEPENDS ON SERUM LEPTIN LEVELS IN ADULTS WITH DIFFERENT NUTRITIONAL-STATUS, The Journal of clinical endocrinology and metabolism, 83(6), 1998, pp. 2006-2011
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
0021-972X
Volume
83
Issue
6
Year of publication
1998
Pages
2006 - 2011
Database
ISI
SICI code
0021-972X(1998)83:6<2006:GHPDDO>2.0.ZU;2-M
Abstract
The aim of this work was to assess the relationship between GH-binding protein (GHBP) and leptin. Both peptides are nutritionally regulated, but the recent implication of a role for leptin in the GH axis requir es further study. To avoid the sexual dimorphism in leptin values, we performed leptin standardization according to gender (SD score-leptin) . The relationship between so score-leptin and GHBP was studied in 128 adults with different nutritional status [8 groups according to body mass index (BMI)], ranging from severely underweight anorexia nervosa to highly morbid obesity. Both GHBP and SD score-leptin significantly increase according to BMI within the range from 18-27 kg/m(2), whereas no significant differences were found among underweight groups (BMI, <18 kg/m(2)) or among obesity grades (BMI, >27 kg/m(2)). We found a st rong correlation between GHBP and SD score-leptin (r = 0.8; P < 0.0001 ). Multiple regression analysis revealed so score-leptin to be a signi ficant determinant of GHBP, accounting for 64% of the variation, where as BMI did not contribute further to explaining changes in GHBP. This suggests a physiological pathway involving both GHBP (the soluble frac tion of GH receptor) and leptin. Thus, we might speculate that leptin could be the signal that induces the related nutritional changes obser ved in GHBP/GH receptor expression.