MUTAGENICITY, CARCINOGENICITY AND TERATOGENICITY OF VANADIUM COMPOUNDS

Citation
A. Leonard et Gb. Gerber, MUTAGENICITY, CARCINOGENICITY AND TERATOGENICITY OF VANADIUM COMPOUNDS, MUTATION RESEARCH, 317(1), 1994, pp. 81-88
Citations number
80
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
ISSN journal
0027-5107
Volume
317
Issue
1
Year of publication
1994
Pages
81 - 88
Database
ISI
SICI code
0027-5107(1994)317:1<81:MCATOV>2.0.ZU;2-A
Abstract
The mutagenic, carcinogenic and teratogenic effects of vanadium and it s compounds are reviewed. It is concluded that vanadium is not clastog enic and only weakly mutagenic; it has marked mitogenic activity affec ting the distribution of chromosomes during mitosis and possibly causi ng aneuploidy. The few positive data on effects of vanadium during dev elopment leave it open whether direct effects on the embryo or fetus o r physiological disturbances in the mother are responsible. No data ex ist indicating that vanadium is carcinogenic in animals or man, but si nce it interferes with mitosis and chromosome distribution, the possib ility that vanadium might be carcinogenic under certain conditions can not be dismissed offhand.