The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1 - A meta-analysis of 15 prospective cohort studies

Authors
Andiman, W Boucher, M Burns, D Bryson, Y Farley, J Fowler, H Gabiano, C Galli, L Hutto, C Kind, C Korber, B Kovacs, A Krogstad, P Landesman, S Lapointe, N Lemay, M Lew, J Mandelbrot, L Mayaux, MJ Mellins, R Minkoff, H Mofenson, L Nielsen, K Newell, ML Pardi, G Peavy, H Peckham, C Read, J Rother, C Rudin, C Scott, G Semprini, A Shearer, W Simonds, R Simpson, B Stek, A Tovo, PA Tuomala, R Van Dyke, R Weedon, J de Martino, M Lindsay, M Belair, S Chan, L Harris, D Kalish, L Muenz, L Nugent, R Schluchter, M Durako, S Goodwin, S Mitchell, R Nourjah, P Owen, W Widmayer, S Bardeguez, A Hanson, C Wiznia, A Luzuriaga, K Viscarello, R Ho, D Koup, R Chen, I Mullins, J Wolinsky, S Walker, B Ammann, A Clapp, S McDonald, D Fauvel, M Hankins, C Samson, J Bailey, A Giaquinto, C Ruga, E De Rossi, A Truscia, D Grosch-Worner, I Schafer, A Mok, J Johnstone, F Jiminez, J de Alba, C Garcia-Rodriguez, M Bates, I de Jose, I Hawkins, F Zapico, RM Asensi-Botet, F Otero, M Perez-Tamarit, D Moya, A Galbis, M Scherpbier, H Boer, K Bohlin, A Lindgren, S Ehrnst, A Anzen, B Belfrage, E Levy, J Alimenti, A Barlow, P Ferrazin, A De Maria, A Gotta, C Maritati, V Mur, A Rovira, M Paya, A Coll, O Fortuny, C Boguna, J Caro, MC Canet, Y Pardi, G Ravizza, M Castagna, C Fiore, S Guerra, B Lanari, M Bianchi, S Bovicelli, L Prati, E Duse, M Soresina, A Scaravelli, G De Santis, M Muggiasca, M Vigano, A Marchisio, P Iasci, A Spinillo, A Bucceri, A Grossi, E Rancilio, L Della Torre, M Dallacasa, P Soresina, A Pachi, A Principi, N Muggiasca, M Marchisio, P Zara, C Vignali, M Rossi, G Rancilio, L Selvaggi, L Greco, P Vimercati, A Massi, G Innocenti, T Fiscella, A Sansone, M Benedetto, C Tibaldi, C Ziarati, N Tadrist, B Thevenicau, D Gondry, J Paulard, B Alisy, C Brault, D Tordjeman, P Mamou, J Rozan, M Colombani, D Pincemaille, O Salvetti, A Chabanier, C Hernandorena, X Leroy, J Schaal, J Balde, P Faucher, P Lachassinne, E Benoit, S Douard, D Hocke, C Barjot, P Brouard, J Delattre, P Stien, L Audibert, F Labrune, P Vial, M Mazy, F Sitbon, D Crenn-Hebert, C Floch-Tudal, C Akakpo, R Daveau, C Leblanc, A Cesbron, P Duval-Arnould, H Huraux-Rendu, C Lemerle, S Touboul, C Guerin, M Maingueneau, C Reynaud, I Rousseau, T Ercoil, V Lanza, M Denavit, M Garnier, J Lahsinat, K Pia, R Allouche, C Nardou, M Grall, F May, A Dallot, M Lhuillier, P Cecile, W Mezin, R Balde, P Bech, A Lobut, J Algava, G Dermesay, AC Busuttil, R Jacquemot, M Bader-Meunier, B Fridman, S Codaccioni, X Maxingue, F Thomas, D Alain, J De Lumley, L Tabaste, J Salin, PB Seaume, H Guichard, A Kebaili, K Roussouly, C Botto, C De Lanete, A Wipff, P Cravello, L De Boisse, P Leclaire, M Michel, G Crumiere, C Lefevre, V Le Lorier, B Pauly, I Robichez, B Seguy, D Dehlinger, M Rideau, F Talon, P Benos, P Huret, C Nicolas, J Heller-Roussin, B Saint-Leger, S Delaporte, M Hubert, C De Sarcus, B Karoubi, P Mechinaud, F Bertcrottiere, D Bongain, A Monpoux, F De Gennes, C Devianne, F Nisand, I Rousset, M Karoubi, P Mouchnino, G Muray, J Munzer, M Quereux, C Brossard, V Clavier, B Allemon, M Rotten, D Stephan, J Varlet, M Guyot, B Narey, P Bardinet, F De Caunes, F Jeny, R Robin, M Bouley, AR Savey, L Berrebi, A Tricoire, J Borderon, J Fignon, A Guillot, F Maria, B Broyard, A Chitrit, Y Firtion, G Mandelbrot, L Pillet, ML Parat, S Boissinot, C Garec, N Levine, M Ottenwalter, A Schaller, F Vilmer, B Courpotin, C Brunner, C Ciraru-Vigneron, N Hatem-Gantzer, G Heller-Roussin, B Fritel, X Wallet, A Bouille, J Milliez, J Mrejen, DB Dermer, E Noseda, G Bardou, D Cressaty, J Francoual, C Moncomble, CC Cohen, H Blanche, S Bastion, H Benifla, J Benkhatar, F Berkane, N Herve, F Ronzier, M Mayaux, MJ de Martino, M Tovo, PA Galli, L Gabiano, C Ferraris, G Rancillo, L Bucceri, A Tulisso, S Scolfaro, C Riva, C Vierucci, A de Luca, M Farina, S Fundaro, C Genovese, O Mercu, G Forni, G Stegagno, M Falconieri, P Zuccotti, G Riva, E Cellini, M Baraldi, C Consolini, R Palla, G Ruggeri, M Pignata, C Guarino, A Osimani, P Metri, A Antonellini, A Benaglia, G Romano, A Dallacasa, P De Mattia, D Caselli, D Boni, S Dell'Erba, G Bassanetti, F Sticca, M Timpano, C Magnani, C Salvatore, C Gambaretto, G Lipreri, R Tornaghi, R Pinzani, R Cecchi, M Bezzi, T Battisti, L Bresciani, E Gattinara, G Berrino, R Pellegatta, A Mazza, A Baldi, F Micheletti, E Ruga, E Altobelli, R Deiana, M Colnaghi, C Tarallo, L Tondo, U Anastasio, E Duse, M Chiriaco, P Contardi, I Ruggeri, C Ibba, P Scott, G Hutto, C O'Sullivan, M Malmsberry, A Willoughby, A Burns, D Goedert, J Landesman, S Minkoff, H Mendez, H Holman, S Rubinstein, A Durako, S Muenz, L Goodwin, S Nesheim, S Lindsay, M Clark, S Lee, F Nahmias, A Sawyer, M Vink, P Farley, J Alger, L Abrams, E Bamji, M Lambert, G Schoenbaum, E Thea, D Thomas, P Weedon, J Palumbo, P Bardeguez, A Denny, T Oleske, J Simonds, R Orloff, S Ethier-Ives, J Rogers, M Schluchter, M Kutner, M Kaplan, S Kattan, M Lipshultz, S Mellins, R Shearer, W Peavy, H Sopko, G Sloand, E Wu, M Kind, C Nadal, D Rudin, C Siegrist, CA Wyler, CA Cheseaux, JJ Aebi, C Gnehm, H Schubiger, G Klingler, J Hunziker, U Kuchler, H Gianinazzi, M Buhlmann, U Rudin, C Biedermann, K Lauper, U Irion, O Brunelli, A Spoletini, G Schreyer, A Kind, C Hosli, I Saurenmann, E Drack, G Isenschmid, M Poorbeik, M Schupbach, J Perrin, L Erb, P Joller, H Bryson, Y Dillon, M Nielsen, R Boyer, P Liao, D Keller, M Deveikis, A Kovacs, A Stek, A Chan, L Rother, C Khoury, M Diaz, C Pacheco-Acosta, E Tuomala, R Cooper, E Mesthene, D Pitt, J Higgins, A Mendez, H Moroso, G Rich, K Turpin, D Cooper, N Fowler, M Nugent, R Smeriglio, V McKinlay, S Kalish, L Ellis, S Andiman, W Simpson, B
Citation
W. Andiman et al., The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1 - A meta-analysis of 15 prospective cohort studies, N ENG J MED, 340(13), 1999, pp. 977-987
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
NEW ENGLAND JOURNAL OF MEDICINE
ISSN journal
0028-4793 → ACNP
Volume
340
Issue
13
Year of publication
1999
Pages
977 - 987
Database
ISI
SICI code
0028-4793(19990401)340:13<977:TMODAT>2.0.ZU;2-5
Abstract
Background To evaluate the relation between elective cesarean section and v ertical transmission of human immunodeficiency virus type 1 (HIV-1), we per formed a meta-analysis using data on individual patients from 15 prospectiv e cohort studies. Methods North American and European studies of at least 100 mother-child pa irs were included in the meta-analysis. Uniform definitions of modes of del ivery were used. Elective cesarean sections were defined as those performed before onset of labor and rupture of membranes. Multivariate logistic-regr ession analysis was used to adjust for other factors known to be associated with vertical transmission. Results The primary analysis included data on 8533 mother-child pairs. Afte r adjustment for receipt of antiretroviral therapy, maternal stage of disea se, and infant birth weight, the likelihood of vertical transmission of HIV -1 was decreased by approximately 50 percent with elective cesarean section , as compared with other modes of delivery (adjusted odds ratio, 0.43; 95 p ercent confidence interval, 0.33 to 0.56). The results were similar when th e study population was limited to those with rupture of membranes shortly b efore delivery. The likelihood of transmission was reduced by approximately 87 percent with both elective cesarean section and receipt of antiretrovir al therapy during the prenatal, intrapartum, and neonatal periods, as compa red with other modes of delivery and the absence of therapy (adjusted odds ratio, 0.13; 95 percent confidence interval, 0.09 to 0.19), Among mother-ch ild pairs receiving antiretroviral therapy during the prenatal, intrapartum , and neonatal periods, rates of vertical transmission were 2.0 percent amo ng the 196 mothers who underwent elective cesarean section and 7.3 percent among the 1255 mothers with other modes of delivery. Conclusions The results of this meta-analysis suggest that elective cesarea n section reduces the risk of transmission of HIV-1 from mother to child in dependently of the effects of treatment with zidovudine. (N Engl J Med 1999 ;340:977-87.) (C)1999, Massachusetts Medical Society.