Successful treatment of cranial metastases of extrapulmonary small cell carcinoma with chemotherapy alone

Citation
B. Orhan et al., Successful treatment of cranial metastases of extrapulmonary small cell carcinoma with chemotherapy alone, MED ONCOL, 15(1), 1998, pp. 66-69
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
MEDICAL ONCOLOGY
ISSN journal
1357-0560 → ACNP
Volume
15
Issue
1
Year of publication
1998
Pages
66 - 69
Database
ISI
SICI code
1357-0560(199804)15:1<66:STOCMO>2.0.ZU;2-K
Abstract
Extrapulmonary small cell carcinoma (EPSCC) is a distinct clinical and path ological entity other than small cell carcinoma of the lung, We present a c ase with EPSCC, with neurologic impairment due to brain metastases at initi al diagnosis, which showed a complete response to combination chemotherapy, A 55-year-old male patient was first admitted with a mass of 6 x 6 cm in d iameter in the right cervical region, The diagnosis of small cell carcinoma was entertained with immunohistopathologic and light microscopic findings, During the period of investigation the tumor showed rapid progression and the patient had neurologic dysfunction with right hemiparesia, and papilla oedema in fundoscopy, Cranial CT showed supratentorial multiple cranial met astases and peritumoral oedema, Since the patient refused radiotherapy, com bination chemotherapy was started (Etoposide 100 mg/sq m i,v,, days 1,3,5 a nd cisplatin 80 mg/sq m i,v,, day 1). A fast response to the chemotherapy w as observed with rapid disappearance of the cervical mass. Following six cy cles of the chemotherapy the patient recovered fully and all the lesions di sappeared with CT.