Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein

Citation
T. Hada et al., Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein, CLIN CHIM A, 281(1-2), 1999, pp. 37-46
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
CLINICA CHIMICA ACTA
ISSN journal
0009-8981 → ACNP
Volume
281
Issue
1-2
Year of publication
1999
Pages
37 - 46
Database
ISI
SICI code
0009-8981(199903)281:1-2<37:DOLCFC>2.0.ZU;2-2
Abstract
We have previously reported that Aleuria aurantia lectin (AAL)-reactive ser um cholinesterase (ChE) activity increases in liver cirrhosis (LC) and hepa tocellular carcinoma (HCC) compared with chronic hepatitis (CH) and normal controls (NC), and measurement of AAL-reactive ChE activity is useful in di scriminating LC from CH. In the present study, Ive have demonstrated that t he measurement of the ratio of AAL-reactive ChE to immuno-reactive ChE prot ein (AAL/ChE) is superior to the measurement of only AAL-reactive ChE for d ifferentiating LC from CH. At a cut-off value of 4.0 arbitrary units of AAL /ChE, the diagnostic accuracy was 87.7%. This diagnostic accuracy is simila r to that of serum hyaluronan, 88.8%. We also examined whether the AAL/ChE measurement is useful for differentiating Child's stage A LC from chronic a ctive hepatitis (CAH) 2B. When mean + 2SD of AAL/ChE in patients with CAH2B was used as a cut-off value for the specific diagnosis of LC, the diagnost ic accuracy was 70.2%. These results demonstrate that measurement of AAL/Ch E is useful for discriminating LC from CH. (C) 1999 Elsevier Science B.V. A ll rights reserved.