Platelet-activating factor (PAF) may influence neuronal migration, and gyra
l anomaly in hemimegalencephaly is believed to result from a neuronal disor
der. A 7-month-old girl with hemimegalencephaly presented with intractable
seizures, for which graded hemispherectomy was performed. In the resected s
pecimen, we could not detect PAF, and related enzyme activities were low. T
hese results suggest a role of PAF in neuronal migration.