Alterations of the retinoic acid receptor alpha (RAR alpha) gene in myeloid and lymphoid malignancies

Citation
A. Parrado et al., Alterations of the retinoic acid receptor alpha (RAR alpha) gene in myeloid and lymphoid malignancies, BR J HAEM, 104(4), 1999, pp. 738-741
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
0007-1048 → ACNP
Volume
104
Issue
4
Year of publication
1999
Pages
738 - 741
Database
ISI
SICI code
0007-1048(199903)104:4<738:AOTRAR>2.0.ZU;2-Y
Abstract
The retinoic acid receptor alpha (RAR alpha) protein plays a central role i n myeloid differentiation, and chromosomal translocations disrupting the RA R alpha gene are implicated in the development of acute myeloid leukaemia ( AML). To identify haemopoietic malignant disorders which may also be linked to RAR alpha abnormalities, Southern blot analysis was performed in DNA fr om 153 patients with haematological malignancies other than AML FAB type M3 using RAR alpha cDNA probes. Alterations of RAR alpha were detected in 1/4 2 myelodysplastic syndromes (MDS), 2/24 AML, 3/47 B-chronic lymphocytic leu kaemias (B-CLL). 0/40 lymphomas and 0/60 normal individuals. These data str ongly suggest that alterations of RAR alpha might predispose for myeloid an d lymphoid disorders.