CHANGES IN LYMPH VESSELS AND PORTAL VEINS IN THE PORTAL TRACT OF PATIENTS WITH IDIOPATHIC PORTAL-HYPERTENSION - A MORPHOMETRIC STUDY

Citation
H. Oikawa et al., CHANGES IN LYMPH VESSELS AND PORTAL VEINS IN THE PORTAL TRACT OF PATIENTS WITH IDIOPATHIC PORTAL-HYPERTENSION - A MORPHOMETRIC STUDY, Hepatology, 27(6), 1998, pp. 1607-1610
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
0270-9139
Volume
27
Issue
6
Year of publication
1998
Pages
1607 - 1610
Database
ISI
SICI code
0270-9139(1998)27:6<1607:CILVAP>2.0.ZU;2-#
Abstract
Little is known about the effects of the pathological process associat ed with idiopathic portal hypertension (IPH) on hepatic lymph vessels or lymph flow We used morphometric analysis to examine IPH-associated changes in lymph vessels and branches of the portal vein, with Use of immunohistochemical staining for alpha smooth muscle actin. We also qu antitated these changes using an image analysis system. The study was conducted with use of liver wedge biopsy material from 10 patients wit h advanced IPH and 10 control samples from patients with gastric carci noma without liver disease. The number of lymph vessels, identified by a lack of smooth muscle layer in the wall, and the ratio of the total area of these vessels to that of the portal tract were higher in IPH samples than in the control samples, but the ratio of the area of a si ngle lymph vessel to that of the portal tract in IPH samples was not d ifferent from control samples. The number of portal vein branches, cha racterized by hypertrophy of the smooth muscle layer in IPH samples wa s not different from control samples. The ratio of the total area of t hese branches to that of the portal tract, and the ratio of a single p ortal vein branch to that of the portal tract, were lower in IPH sampl es than in the control samples. Our results suggest that these morphom etric changes in IPH may be associated with a reduction in portal bloo d flow and increased lymph flow and that the latter may in turn reduce the high portal vein pressure in idiopathic portal hypertension.