OVARIECTOMY-INDUCED HYPERALGESIA AND ANTINOCICEPTIVE EFFECT OF ELCATONIN, A SYNTHETIC EEL CALCITONIN

Citation
K. Shibata et al., OVARIECTOMY-INDUCED HYPERALGESIA AND ANTINOCICEPTIVE EFFECT OF ELCATONIN, A SYNTHETIC EEL CALCITONIN, Pharmacology, biochemistry and behavior, 60(2), 1998, pp. 371-376
Citations number
56
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Behavioral Sciences
ISSN journal
0091-3057
Volume
60
Issue
2
Year of publication
1998
Pages
371 - 376
Database
ISI
SICI code
0091-3057(1998)60:2<371:OHAAEO>2.0.ZU;2-B
Abstract
Using ovariectomized (OVX) rats in the tail-withdrawal nociceptive tes t, we examined OVX induced hyperalgesia and the antinociceptive effect of subcutaneously administered elcatonin, a synthetic derivative of e el calcitonin ([AsU1.7] eel calcitonin). Because tail-withdrawal laten cy was significantly and continuously reduced and bone mineral density decreased in OVX rats compared with those of sham-operated rats, it w as demonstrated that ovariectomy induced prolonged hyperalgesia and os teoporosis. After repeated administrations for 3 or 4 weeks, subcutane ously injected elcatonin increased the latency of the OVX rats in a do se-dependent manner, compared to the vehicle-treated OVX rats. At a do se of 20 U/kg/day, there were significant differences (p < 0.01) in th e latency between the elcatonin- and vehicle-treated OVX rats. This ef fect of elcatonin was completely inhibited by p-chlorophenylalanine tr eatment, suggesting that the central serotonergic system may be involv ed in the elcatonin antinociception of OVX-induced hyperalgesia. (C) 1 998 Elsevier Science Inc.