SUBSTRATE-SPECIFICITY OF HUMAN PROLYL-4-HYDROXYLASE

Citation
M. Tandon et al., SUBSTRATE-SPECIFICITY OF HUMAN PROLYL-4-HYDROXYLASE, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1139-1144
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
ISSN journal
0960-894X
Volume
8
Issue
10
Year of publication
1998
Pages
1139 - 1144
Database
ISI
SICI code
0960-894X(1998)8:10<1139:SOHP>2.0.ZU;2-0
Abstract
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me , and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl- 4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were su bstrates for the enzyme. (C) 1998 Elsevier Science Ltd. All rights res erved.