GROWTH-PATTERNS AND GENETIC CHANGES OF COLORECTAL-CARCINOMA

Citation
K. Kaneko et al., GROWTH-PATTERNS AND GENETIC CHANGES OF COLORECTAL-CARCINOMA, Japanese Journal of Clinical Oncology, 28(3), 1998, pp. 196-201
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0368-2811
Volume
28
Issue
3
Year of publication
1998
Pages
196 - 201
Database
ISI
SICI code
0368-2811(1998)28:3<196:GAGCOC>2.0.ZU;2-Y
Abstract
Background: Recent Japanese studies have shown that histogenesis of sm all colorectal carcinomas can be divided into two groups: polypoid gro wth arising from polypoid neoplasia, and nonpolypoid growth arising fr om flat or depressed neoplasia, This classification should be verified with genetic as well as morphologic characteristics. Subjects and Met hods: In order to classify our subject into polypoid growth and nonpol ypoid growth types both histologically and endoscopically, we selected 42 colorectal carcinomas <2 cm in size (35 submucosal and seven more advanced), Clinicopathological findings, presence or absence of Ki-ras gene mutation and overexpression of p53 protein were compared between the two types. Results: Histologically, the cases were divided into 2 7 of the polypoid growth type and 15 of the nonpolypoid growth type, N one of the nonpolypoid growth cases contained adenomatous remnant, whe reas this was found in 75% of the polypoid growth cases. No Ki-ras mut ation was observed in any of the nonpolypoid growth cases, although it appeared in 44% of the polypoid growth cases, Regarding the overexpre ssion of p53 protein, no significant difference was observed between t he two types. The histological and the colonoscopic polypoid growth-no npolypoid growth classifications correlated well with each other (agre ement rate 98%), except for one lesion, which was classified as polypo id growth type endoscopically but as nonpolypoid growth type histologi cally. Conclusions: The histologically defined polypoid growth-nonpoly poid growth classification may indicate a difference in pathway of col orectal carcinogenesis. Also, colonoscopic polypoid growth-nonpolypoid growth classification is available for preoperative estimation of the genetic characteristics of small carcinomas.