IS COLONOSCOPIC SURVEILLANCE REDUCING COLORECTAL-CANCER MORTALITY IN ULCERATIVE-COLITIS - A POPULATION-BASED CASE-CONTROL STUDY

Citation
P. Karlen et al., IS COLONOSCOPIC SURVEILLANCE REDUCING COLORECTAL-CANCER MORTALITY IN ULCERATIVE-COLITIS - A POPULATION-BASED CASE-CONTROL STUDY, Gut, 42(5), 1998, pp. 711-714
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
GutACNP
ISSN journal
0017-5749
Volume
42
Issue
5
Year of publication
1998
Pages
711 - 714
Database
ISI
SICI code
0017-5749(1998)42:5<711:ICSRCM>2.0.ZU;2-1
Abstract
Background-Colonoscopic surveillance is a standard procedure in many p atients with long standing, extensive ulcerative colitis (UC), in orde r to avoid death from colorectal cancer. No conclusive proof of its be nefits has been presented however. Aims-To evaluate the association be tween colonoscopic surveillance and colorectal cancer mortality in pat ients with UC. Patients-A population based, nested case control study comprising 142 patients with a definite UC diagnosis, derived from a s tudy population of 4664 patients with UC, was conducted. Methods-Colon oscopic surveillance in all patients with UC who had died from colorec tal cancer after 1975 was compared with that in controls matched for a ge, sex, extent, and duration of the disease. Information on colonosco pic surveillance was obtained from the medical records. Results-Two of 40 patients with UC and 18 of 102 controls had undergone at least one surveillance colonoscopy (relative risk (RR) 0.29, 95% confidence int erval 0.06 to 1.31). Twelve controls but only one patient with UC had undergone two or more surveillance colonoscopies (RR 0.22, 95% confide nce interval 0.03 to 1.74), indicating a protective dose response rela tion. Conclusion-Colonoscopic surveillance may be associated with a de creased risk of death from colorectal cancer in patients with long sta nding UC.