NEURODEGENERATION INDUCED BY REVERSED MICRODIALYSIS OF NMDA - A QUANTITATIVE MODEL FOR EXCITOTOXICITY IN-VIVO

Citation
I. Vanicky et al., NEURODEGENERATION INDUCED BY REVERSED MICRODIALYSIS OF NMDA - A QUANTITATIVE MODEL FOR EXCITOTOXICITY IN-VIVO, Brain research, 789(2), 1998, pp. 347-350
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
Volume
789
Issue
2
Year of publication
1998
Pages
347 - 350
Database
ISI
SICI code
Abstract
This study characterizes a quantifiable in vivo model of excitotoxicit y. In halothane anesthetized rats, microdialysis probe was implanted i nto somatosensory cortex/striatum and perfused by various concentratio ns (1, 10, 50 and 100 mmol/l) of N-methyl-D-aspartate (NMDA) for 20 mi n. After 24 h, histological quantification confirmed that NMDA produce d a concentration-dependent excitotoxic lesion. With 10 mmol/l NMDA, c oadministration of magnesium reduced significantly, and 2-amino-5-phos phonovalerate blocked completely the development of excitotoxic injury . (C) 1998 Elsevier Science B.V.