EFFECTS OF TESTOSTERONE AND PROGESTERONE ON BRAIN 5-ALPHA-REDUCTASE AND AROMATASE IN LONG-EVANS MALES AND COMPARISON OF AROMATASE IN LONG-EVANS VS. SPRAGUE-DAWLEY RATS

Citation
Ed. Lephart et al., EFFECTS OF TESTOSTERONE AND PROGESTERONE ON BRAIN 5-ALPHA-REDUCTASE AND AROMATASE IN LONG-EVANS MALES AND COMPARISON OF AROMATASE IN LONG-EVANS VS. SPRAGUE-DAWLEY RATS, Brain research, 789(2), 1998, pp. 327-330
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
Volume
789
Issue
2
Year of publication
1998
Pages
327 - 330
Database
ISI
SICI code
Abstract
We investigated medial basal hypothalamic-preoptic area (MBH-POA) 5 al pha-reductase and aromatase enzyme activities in gonadally intact and castrated adult Long-Evans (L-E) male rats treated with testosterone ( T), progesterone (P), and a combination of T + P. MBH-POA 5 alpha-redu ctase and aromatase activities did not differ significantly among the groups. The lack of a difference in MBH-POA aromatase between control and castrated L-E animals was unexpected. In two further experiments, MBH-POA aromatase was examined in intact and castrated L-E and Sprague -Dawley (S-D) rats, using direct and indirect assays. The activity in castrated S-D (but again, not in L-E) rats significantly decreased com pared to control values. These data suggest that the absence of gonads does not decrease MBH-POA aromatase in adult L-E rats. (C) 1998 Elsev ier Science B.V.