GLIAL AND NEURONAL LOCALIZATION OF NEURONAL NITRIC-OXIDE SYNTHASE IMMUNOREACTIVITY IN THE MEDIAN-EMINENCE OF FEMALE RATS

Citation
S. Kawakami et al., GLIAL AND NEURONAL LOCALIZATION OF NEURONAL NITRIC-OXIDE SYNTHASE IMMUNOREACTIVITY IN THE MEDIAN-EMINENCE OF FEMALE RATS, Brain research, 789(2), 1998, pp. 322-326
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
Volume
789
Issue
2
Year of publication
1998
Pages
322 - 326
Database
ISI
SICI code
Abstract
Localization of neuronal nitric oxide synthase-immunoreactivity (nNOS- IR) in the median eminence of female rats (n = 4) was examined by elec tron microscopy to explore the possibility that nitric oxide is involv ed in the terminal regulation of neurosecretory peptides such as GnRH. Under light microscopy, a dense distribution of nNOS-IR was observed in this region. Electronmicroscopically, nNOS-IR was found in glial el ements and nerve terminals containing dense-core vesicles. We also fou nd a few nNOS-immunopositive synapses, in which intense immunoreactivi ty was found on the postsynaptic density and mitochondrial membrane. T he localization of nNOS-IR in nerve terminals and glial elements in th e median eminence might indicate that nNOS plays a role in regulating the release of neurosecretory peptide. (C) 1998 Elsevier Science B.V.