INFLUENCE OF DIETARY ZINC ON CONVULSIVE SEIZURES AND HIPPOCAMPAL NADPH DIAPHORASE-POSITIVE NEURONS IN SEIZURE-SUSCEPTIBLE EL MOUSE

Citation
I. Nagatomo et al., INFLUENCE OF DIETARY ZINC ON CONVULSIVE SEIZURES AND HIPPOCAMPAL NADPH DIAPHORASE-POSITIVE NEURONS IN SEIZURE-SUSCEPTIBLE EL MOUSE, Brain research, 789(2), 1998, pp. 213-220
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
Volume
789
Issue
2
Year of publication
1998
Pages
213 - 220
Database
ISI
SICI code
Abstract
Adequate, high and deficient dietary levels of zinc (Zn) were compared in seizure-susceptible EL mice with respect to convulsions and to nic otinamide adenine dinucleotide phosphate (NADPH) diaphorase-positive h ippocampal neurons. Diaphorase positivity is associated with nitric ox ide (NO) production. Convulsive seizures in the EL mice given the vari ous diets did not differ over 1-4 weeks, but convulsions in EL mice gi ven the Zn-deficient diet for 4 weeks were mon effectively suppressed by injection of zonisamide (ZNS) (75 mg/kg intraperitoneally) than in mice receiving high- or adequate-Zn diet for the same period. Numbers of NADPH diaphorase-positive neurons in the CA1/CA2 region of the hipp ocampal formation were significantly higher in mice given the Zn-defic ient diet for 4 weeks than in mice fed adequate Zn. Mice receiving the high-Zn diet for the same period had significantly fewer NADPH diapho rase-positive neurons in the subiculum than mice with adequate Zn. The se results suggest that Zn deficiency inhibits convulsive seizures of EL mice, and that dietary Zn influences numbers of NO producing neuron s in the hippocampal formation. (C) 1998 Elsevier Science B.V.