PULSATILE FLOW COMPUTATIONAL SIMULATIONS OF MITRAL REGURGITATION

Citation
J. Hopmeyer et al., PULSATILE FLOW COMPUTATIONAL SIMULATIONS OF MITRAL REGURGITATION, Journal of biomechanical engineering, 120(2), 1998, pp. 245-254
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Engineering, Biomedical",Biophysics
ISSN journal
0148-0731
Volume
120
Issue
2
Year of publication
1998
Pages
245 - 254
Database
ISI
SICI code
0148-0731(1998)120:2<245:PFCSOM>2.0.ZU;2-L
Abstract
The noninvasive quantification of mitral regurgitation remains an impo rtant clinical goal. Recently, the flow convergence method was develop ed to estimate the regurgitant flow rate. This study used three-dimens ional pulsatile computational simulations to evaluate the accuracy of the flow convergence method in the presence of complicating factors su ch as ventricular confinement, noncircular orifice shape, and the pres ence of aortic outflow. Results showed that in the absence of aortic o utflow and ventricular confinement, there was a plateau zone where the calculated flow rate by the hemispheric formula approximated the true flow rate, independent of the orifice shape. In the presence of aorti c outflow and in chambers of physiologic dimensions, there was no long er a clear zone where the hemispheric formula was valid. The hemi-elli ptic modification of the flow convergence method worked in all cases, independent of the degree of ventricular confinement or the presence o f aortic outflow. Therefore, application of the hemi-elliptic formula should be considered in future clinical studies.