INTERLEUKIN-10 PRODUCTION DURING AND AFTER UPPER ABDOMINAL-SURGERY

Citation
M. Kato et al., INTERLEUKIN-10 PRODUCTION DURING AND AFTER UPPER ABDOMINAL-SURGERY, Journal of clinical anesthesia, 10(3), 1998, pp. 184-188
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
ISSN journal
0952-8180
Volume
10
Issue
3
Year of publication
1998
Pages
184 - 188
Database
ISI
SICI code
0952-8180(1998)10:3<184:IPDAAU>2.0.ZU;2-G
Abstract
Study Objective: To evaluate the influence of major abdominal surgery on the plasma levels of interleukin-10 (IL-10). Design: Prospective st udy. Setting: University hospital. Patients: 10 ASA physical status I and II patients undergoing upper abdominal surgery. Interventions: All patients received combined general-epidural anesthesia with isofluran e and nitrous oxide, after insertion of an epidural catheter at T-8-T- 9 dosed with 1.5% lidocaine. Measurements and Main Results: Plasma int erleukin-6 (IL-6), interleukin-8 (IL-8) and IL-10 levels were determin ed with an enzyme-linked immunosorbent assay at preanesthesia, 0, 2 an d 4 hours during surgery, and at the end of surgery, followed by sampl ing on the morning of postoperative days 1 (POD1) and 3 (POD3). Before anesthesia and at 0 hours of surgery, IL-10 was not detected. In all ten patients, the plasma levels of IL-10 showed significant elevations and achieved their maximal value 4 hours after-the skin incision (p < 0.05 vs. baseline). The plasma IL-10 levels returned to preanesthesia levels on POD3. The plasma levels of IL-6 and IL-8 also increased in t he perioperative period. The peak cytokine levels correlated (r = 0.91 5, p = 0.0001 for IL-6 vs. IL-8; r = 0.82, p = 0.025 for IL-6 vs. IL-1 0; and r = 0.641, p = 0.06 for IL-8 vs: IL-10). The peak plasma IL-10 levels significantly correlated with the amount of intraoperative bloo d loss (r = 0.69, p <0.05). Conclusions: In patients undergoing major abdominal surgery, plasma IL-10 levels were elevated during and after operation. IL-10 may modulate the inflammatory responses in the periop erative period. (C) 1998 by Elsevier Science Inc.