INCREASED PREVALENCE OF IMMUNOGLOBULIN-A DEFICIENCY IN PATIENTS WITH THE CHROMOSOME 22Q11.2 DELETION SYNDROME (DIGEORGE-SYNDROME VELOCARDIOFACIAL SYNDROME)

Citation
Ca. Smith et al., INCREASED PREVALENCE OF IMMUNOGLOBULIN-A DEFICIENCY IN PATIENTS WITH THE CHROMOSOME 22Q11.2 DELETION SYNDROME (DIGEORGE-SYNDROME VELOCARDIOFACIAL SYNDROME), Clinical and diagnostic laboratory immunology, 5(3), 1998, pp. 415-417
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology,"Infectious Diseases",Microbiology
ISSN journal
1071-412X
Volume
5
Issue
3
Year of publication
1998
Pages
415 - 417
Database
ISI
SICI code
1071-412X(1998)5:3<415:IPOIDI>2.0.ZU;2-#
Abstract
We wished to determine the prevalence of immunoglobulin A (IgA) defici ency in patients with the chromosome 22q11.2 deletion syndrome. A tota l of 32 patients with the chromosome 22q11.2 deletion were examined fo r IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in t his population is 14.20 (P < 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodefi ciency.