INCREASED PREVALENCE OF IMMUNOGLOBULIN-A DEFICIENCY IN PATIENTS WITH THE CHROMOSOME 22Q11.2 DELETION SYNDROME (DIGEORGE-SYNDROME VELOCARDIOFACIAL SYNDROME)
Ca. Smith et al., INCREASED PREVALENCE OF IMMUNOGLOBULIN-A DEFICIENCY IN PATIENTS WITH THE CHROMOSOME 22Q11.2 DELETION SYNDROME (DIGEORGE-SYNDROME VELOCARDIOFACIAL SYNDROME), Clinical and diagnostic laboratory immunology, 5(3), 1998, pp. 415-417
We wished to determine the prevalence of immunoglobulin A (IgA) defici
ency in patients with the chromosome 22q11.2 deletion syndrome. A tota
l of 32 patients with the chromosome 22q11.2 deletion were examined fo
r IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency
in patients with this syndrome. The odds ratio of IgA deficiency in t
his population is 14.20 (P < 0.0001). This confirms the occurrence of
significant humoral deficits in this predominantly cellular immunodefi
ciency.