ORAL-CONTRACEPTIVE USE AND RISK OF COLORECTAL-CANCER

Citation
E. Fernandez et al., ORAL-CONTRACEPTIVE USE AND RISK OF COLORECTAL-CANCER, Epidemiology, 9(3), 1998, pp. 295-300
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public, Environmental & Occupation Heath
Journal title
ISSN journal
1044-3983
Volume
9
Issue
3
Year of publication
1998
Pages
295 - 300
Database
ISI
SICI code
1044-3983(1998)9:3<295:OUAROC>2.0.ZU;2-D
Abstract
To evaluate the relation between oral contraceptives and colon and rec tal cancer, we analyzed combined data from two case-control studies co nducted in six Italian regions between 1985 and 1996. The studies incl uded 803 women with incident colon cancer, 429 with rectal cancer, and 2,793 controls with acute, nonneoplastic, nondigestive, non-hormone-r elated disorders. We estimated odds ratios (ORs) and 95% confidence in tervals (CIs) from unconditional multiple logistic regression equation s, including terms for age, center/study period, education, family his tory of colorectal cancer, menopausal status, age at menopause, parity , use of hormone replacement therapy, body mass index [weight (kg) per height squared (m(2))], and total energy intake. Ever-use of oral con traceptives was inversely associated with colon cancer (OR = 0.63; 95% CI = 0.45-0.87) and rectal cancer (OR = 0.66; 95% CI = 0.43-1.01). Du ration of use of oral contraceptives was inversely related to risk of colon but not rectal cancer. This study suggests that women who have e ver used oral contraceptives are at lower risk of colon and rectal can cer.