SYNTHESIS OF THE 9-FLUORO-9-DEOXY-4-DEMETHOXYDAUNORUBICINONE AND ITS GLYCOSIDES

Authors
Citation
G. Giannini, SYNTHESIS OF THE 9-FLUORO-9-DEOXY-4-DEMETHOXYDAUNORUBICINONE AND ITS GLYCOSIDES, Gazzetta chimica italiana, 127(10), 1997, pp. 545-546
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
ISSN journal
0016-5603
Volume
127
Issue
10
Year of publication
1997
Pages
545 - 546
Database
ISI
SICI code
0016-5603(1997)127:10<545:SOT9AI>2.0.ZU;2-O
Abstract
An aglycone substituted with a fluorine atom at position 9 has been sy nthesized. The two epimeric 7-OH aglycones 3, and 4 gave, after glycos idation with daunosamine, 5, the four diastereoisomeric glycosides 6-9 : (7S,9S)-, (7R,9R)-, (7S,9R)-; (7R,9S)-9-fluoro-9-deoxy-4-demethoxy d aunorubicin derivatives.