An aglycone substituted with a fluorine atom at position 9 has been sy
nthesized. The two epimeric 7-OH aglycones 3, and 4 gave, after glycos
idation with daunosamine, 5, the four diastereoisomeric glycosides 6-9
: (7S,9S)-, (7R,9R)-, (7S,9R)-; (7R,9S)-9-fluoro-9-deoxy-4-demethoxy d
aunorubicin derivatives.