HORMONE REPLACEMENT THERAPY AND RISK OF COLON AND RECTAL-CANCER

Citation
E. Fernandez et al., HORMONE REPLACEMENT THERAPY AND RISK OF COLON AND RECTAL-CANCER, Cancer epidemiology, biomarkers & prevention, 7(4), 1998, pp. 329-333
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Public, Environmental & Occupation Heath
ISSN journal
1055-9965
Volume
7
Issue
4
Year of publication
1998
Pages
329 - 333
Database
ISI
SICI code
1055-9965(1998)7:4<329:HRTARO>2.0.ZU;2-P
Abstract
The hypothesis that sex hormones may influence colorectal cancer risk was formulated in the early 1980s, but epidemiological,studies on a re lationship between. colorectal cancer risk and hormone replacement the rapy (HRT) have only accumulated over the last few years, To investiga te the relationship between HRT and colon and rectal cancer and the ro le of other covariates that might modify it, we analyzed combined data from two case-control studies conducted in Italy between 1985 and 199 6, including 994 women with incident colon cancer, 542 with rectal can cer, and 3110 controls with acute, nonneoplastic, nondigestive, non-ho rmone-related disorders. Odds ratios (ORs) and 95% confidence interval s (CIs) were derived from unconditional multiple logistic regression e quations including terms for age, center/study period, education, fami ly history of,colorectal cancer, status and age at menopause, parity, use of oral contraceptives, total energy intake, and body mass index, Ever use of HRT was inversely associated with cancer of the colon (OR = 0.64, 95% CI = 0.46-0.88) and of the rectum (OR = 0.46, 95% CI = 0.2 9-0.72), Increasing duration of nse of HRT was related to decreasing r isk for colon and rectal cancers (P for trend < 0.72). No interaction emerged, and the inverse association persisted across separate strata of other risk factors, This study, one of the largest case-control inv estigations on exogenous female;hormones and colorectal cancer thus fa r, provides further evidence that women who have ever used HRT are at lower risk of colon and rectal cancer, Because colorectal cancer is th e second most common neoplasm and cause of death among nonsmoking wome n in developed countries, these results may have a major public health impact.