ANTIHYPERGLYCEMIC EFFECTS OF N-CONTAINING SUGARS FROM XANTHOCERCIS-ZAMBESIACA, MORUS-BOMBYCIS, AGLAONEMA-TREUBII, AND CASTANOSPERMUM-AUSTRALE IN STREPTOZOTOCIN-DIABETIC MICE

Citation
H. Nojima et al., ANTIHYPERGLYCEMIC EFFECTS OF N-CONTAINING SUGARS FROM XANTHOCERCIS-ZAMBESIACA, MORUS-BOMBYCIS, AGLAONEMA-TREUBII, AND CASTANOSPERMUM-AUSTRALE IN STREPTOZOTOCIN-DIABETIC MICE, Journal of natural products, 61(3), 1998, pp. 397-400
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
0163-3864
Volume
61
Issue
3
Year of publication
1998
Pages
397 - 400
Database
ISI
SICI code
0163-3864(1998)61:3<397:AEONSF>2.0.ZU;2-3
Abstract
The aqueous MeOH extract of the leaves and root of Xanthocercis zambes iaca (Leguminosae) and eight structurally related nitrogen-containing sugars, fagomine (1), 4-O-beta-D-glucopyranosylfagomine sylfagomine (2 ), 3-O-beta-D-glucopyranosylfagomine (3), 3-epifagomine (4), 2,5-dideo xy-2,5-imino-D-mannitol (5), castanospermine (6), alpha-homonojirimyci n (7), and 1-deoxynojirimycin (8) were evaluated for antihyperglycemic effects in streptozotocin (STZ)-diabetic mice. The insulin-releasing effects of I were also investigated. The blood glucose level fell afte r ip injection of the extract (50 mg/kg). Compounds 1, 2, 5, and 6 red uced the blood glucose level after ip injection of 150 mu mol/kg. Comp ound 1 increased plasma insulin level in STZ-diabetic mice and potenti ated the 8.3-mM glucose-induced insulin release from the rat isolated- perfused pancreas. The 1-induced potentiation of insulin release may p artly contribute to antihyperglycemic action.