BIOLOGY OF TGF-BETA IN KNOCKOUT AND TRANSGENIC MOUSE MODELS

Citation
Ep. Bottinger et al., BIOLOGY OF TGF-BETA IN KNOCKOUT AND TRANSGENIC MOUSE MODELS, Kidney international, 51(5), 1997, pp. 1355-1360
Citations number
69
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
0085-2538
Volume
51
Issue
5
Year of publication
1997
Pages
1355 - 1360
Database
ISI
SICI code
0085-2538(1997)51:5<1355:BOTIKA>2.0.ZU;2-C
Abstract
This paper reviews the basic biology and biochemistry of the TGF-P iso forms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-beta expression and/or recepotr/si gnaling function have been implicated in a wide variety of pathologies . We will discuss mechanisms underlying some of these disease processe s as gained from study of transgenic mice in which expression of TGF-b eta 1 has either been lost by targeted deletion of its gene, is overex pressed in a tissue-specific manner, or blocked by its latency associa ted peptide.