ACETONE CHEMICAL-IONIZATION MASS-SPECTROMETRY

Citation
S. Prabhakar et M. Vairamani, ACETONE CHEMICAL-IONIZATION MASS-SPECTROMETRY, Mass spectrometry reviews, 16(5), 1997, pp. 259-281
Citations number
106
Language
INGLESE
art.tipo
Review
Journal title
ISSN journal
0277-7037
Volume
16
Issue
5
Year of publication
1997
Pages
259 - 281
Database
ISI
SICI code
0277-7037(1997)16:5<259:ACM>2.0.ZU;2-X
Abstract
Chemical ionization mass spectrometry (CIMS) is often used for the cha racterization of thermally stable and electron impact-labile compounds , and acetone is one of the CI reagent gases used not only to characte rize the analytes but also to differentiate regio-and stereoisomers. T he nature of the reagent ions, the factors affecting the reagent plasm a, and the type of ion-molecule reactions with the substrate molecules under acetone/CI are briefly discussed in this article. The ion-molec ule reactions between the reagent ions and a wide variety of organic c ompounds are reviewed. The mechanisms involved in the formation of cha racteristic ions studied by using acetone-d(6) as a reagent and also b y collision-induced dissociation of the respective adduct ions have be en discussed. The site of acetylation in most of the substrates by the reagent ions of acetone has been found to depend on the nature and po sition of the substituents present in the substrate, and in some cases the acetylation reaction is controlled by the steric factors. (C) 199 8 John Wiley & Sons, Inc.