INCREASED ENDOTHELIN ETA-RECEPTOR EXPRESSION IN RAT CAROTID ARTERIES AFTER BALLOON INJURY

Citation
M. Viswanathan et al., INCREASED ENDOTHELIN ETA-RECEPTOR EXPRESSION IN RAT CAROTID ARTERIES AFTER BALLOON INJURY, Peptides, 18(2), 1997, pp. 247-255
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology
Journal title
ISSN journal
0196-9781
Volume
18
Issue
2
Year of publication
1997
Pages
247 - 255
Database
ISI
SICI code
0196-9781(1997)18:2<247:IEEEIR>2.0.ZU;2-2
Abstract
Endothelins are vasoactive peptides and are believed to act as vascula r smooth muscle mitogens. Vascular injury results in medial smooth mus cle migration and proliferation with the formation of a neointima. Usi ng quantitative autoradiography, we examined the expression of endothe lin receptor subtypes ETA and ETB in the rat carotid artery 2, 8, and 16 days after balloon- catheter injury. At two and eight days after ba lloon catheterization, ETA receptor expression was significantly incre ased in the media of the injured vessel when compared to that in the m edia of the intact vessel. The enhanced expression of receptors return ed to normal levels by 16 days after the injury. Neointimal cells also expressed ETA receptors at a lower lever than that expressed by the i njured media 8 days after injury, and continued to express ETA recepto rs 16 days after the injury. ETB receptors were not detectable in the media or the neointima at any time after the injury. Our results sugge st that ETA receptors may have a significant role in injury induced va scular smooth muscle proliferation and neointima formation. Published by Elsevier Science Inc.