TGF-BETA KNOCKOUT AND DOMINANT-NEGATIVE RECEPTOR TRANSGENIC MICE

Citation
Jj. Letterio et Ep. Bottinger, TGF-BETA KNOCKOUT AND DOMINANT-NEGATIVE RECEPTOR TRANSGENIC MICE, Mineral and electrolyte metabolism, 24(2-3), 1998, pp. 161-167
Citations number
56
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
0378-0392
Volume
24
Issue
2-3
Year of publication
1998
Pages
161 - 167
Database
ISI
SICI code
0378-0392(1998)24:2-3<161:TKADRT>2.0.ZU;2-I
Abstract
Use of homologous recombination and transgenic technologies have provi ded mouse models to study the physiological roles of the three mammali an TGF-beta isoforms, and their regulation in the context of the intac t animal. Mice harboring null mutations for TGF-beta isoforms demonstr ate that each exerts discrete nonoverlapping functions during developm ent. TGF-beta 1 null mice reveal a crucial role for this cytokine in m odulation of the immune system, with evidence for altered development, activation and function of various immune cell populations. New appro aches to tissue-and cell-restricted disruption of TGF-beta signaling p athways in transgenic mice carrying dominant-negative mutant TGF-beta receptors will be discussed.