Aberrant expression of TGF-beta and/or receptor/signaling function is
present in a wide variety of disease processes, Overexpression of TGF-
beta isoforms in transgenic mice using tissue-specific promoters has p
rovided model systems to study the effects of increased activity of TG
F-beta in the intact organism. We will review the pertinent features o
f some of these models, and discuss new insights provided by these stu
dies into regulation and role of TGF-beta in health and disease.