LESSONS FROM TGF-BETA TRANSGENIC MICE

Citation
Ep. Bottinger et Jb. Kopp, LESSONS FROM TGF-BETA TRANSGENIC MICE, Mineral and electrolyte metabolism, 24(2-3), 1998, pp. 154-160
Citations number
52
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
0378-0392
Volume
24
Issue
2-3
Year of publication
1998
Pages
154 - 160
Database
ISI
SICI code
0378-0392(1998)24:2-3<154:LFTTM>2.0.ZU;2-K
Abstract
Aberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes, Overexpression of TGF- beta isoforms in transgenic mice using tissue-specific promoters has p rovided model systems to study the effects of increased activity of TG F-beta in the intact organism. We will review the pertinent features o f some of these models, and discuss new insights provided by these stu dies into regulation and role of TGF-beta in health and disease.