PLATELET EPIDERMAL GROWTH-FACTOR IN THYROID-DISORDERS

Citation
M. Okada et al., PLATELET EPIDERMAL GROWTH-FACTOR IN THYROID-DISORDERS, Endocrine journal, 45(1), 1998, pp. 83-88
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology & Metabolism
Journal title
ISSN journal
0918-8959
Volume
45
Issue
1
Year of publication
1998
Pages
83 - 88
Database
ISI
SICI code
0918-8959(1998)45:1<83:PEGIT>2.0.ZU;2-N
Abstract
We evaluated the concentration of epidermal growth factor (EGF) in pla telets, serum and plasma obtained from 47 patients with Graves' diseas e, 7 with hypothyroidism and 20 healthy subjects. The platelets of the subjects were collected from platelet rich plasma and lysed by freezi ng and thawing. Subsequently the platelet debris was treated with Trit on X-100. The EGF concentration was determined by homologous radioimmu noassay. The concentration of EGF in the platelets in 14 patients with untreated Graves' disease was significantly higher than that in the h ealthy controls. After treating these 14 patients with antithyroid age nts, the EGF concentration in the platelets decreased to the level of the healthy controls. The EGF concentration in the platelets in the 7 untreated hypothyroid patients decreased after replacement therapy wit h thyroxine. The mean volume of the platelets in the 14 patients with unheated Graves' disease was significantly larger than in the control and decreased after treatment with antithyroid agents. The serum and p lasma levels of EGF in the 7 untreated hypothyroid increased after rep lacement therapy. In conclusion, thyroid function affected the concent ration of EGF in the platelets of patients with thyroid disorders.