POPULATION ATTRIBUTABLE RISK FOR BREAST-CANCER - DIET, NUTRITION, ANDPHYSICAL EXERCISE

Citation
M. Mezzetti et al., POPULATION ATTRIBUTABLE RISK FOR BREAST-CANCER - DIET, NUTRITION, ANDPHYSICAL EXERCISE, Journal of the National Cancer Institute, 90(5), 1998, pp. 389-394
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Volume
90
Issue
5
Year of publication
1998
Pages
389 - 394
Database
ISI
SICI code
Abstract
Background: The percentages of breast cancer cases in a given populati on attributable to specific risk factors (i,e,, the population-attribu table risks) can be calculated; determination of such risks associated with potentially modifiable risks factors, such as diet (e,g,, levels of consumption of fruits, vegetables, vitamins, etc.), alcohol consum ption, exercise, and body weight, are necessary to focus prevention st rategies, Methods: With the use of data from a case-control study cond ucted in Italy from June 1991 through April 1994 on 2569 breast cancer case subjects and 2588 control subjects, we calculated multivariate o dds ratios and population-attributable risks for breast cancer in rela tion to dietary beta-carotene and vitamin E intake, alcohol consumptio n, physical activity, and, for postmenopausal women, body mass index, Results: Among all subjects, the following attributable risks for the indicated risk factors were observed: 10.7% (95% confidence interval [ CI] = 4.4%-17.0%) for high alcohol intake (i,e,, >20 g/day), 15.0% (95 % CI = 7.4%-22.9%) for low beta-carotene intake (i,e,, <3366 mu g/day ), 8.6% (95% CI = -0.4%-17.5%) for low vitamin E intake (i,e,, <8.5 mg /day), and 11.6% (95 % CI = -0.1%-23.3%) for low levels of physical ac tivity, The risks associated with alcohol and beta-carotene intake wer e larger among premenopausal women, and the risk associated with physi cal activity was larger among postmenopausal women, Being overweight a ccounted for 10.2% (95% CI = 0.2%-20.2%) of breast cancer cases in pos tmenopausal women, beta-Carotene plus alcohol accounted for 28.1% (95% CI = 16.8-39.4) of the cases, beta-Carotene and physical activity acc ounted for 32% (95% CI = 14.3-49.8), and these three factors together accounted for 33% (95% CI = 19.9-46.1) of the breast cancer cases in t he overall dataset, Conclusion: Exposure to a few selected and potenti ally modifiable risk indicators explained about one third of the cases of breast cancer in this Italian population, indicating the theoretic al scope for prevention of the disease.