REDUCTION IN TRANSFORMING-GROWTH-FACTOR-BETA RECEPTOR-I EXPRESSION AND TRANSCRIPTION FACTOR CBFA1 ON BONE-CELLS BY GLUCOCORTICOID

Citation
Dj. Chang et al., REDUCTION IN TRANSFORMING-GROWTH-FACTOR-BETA RECEPTOR-I EXPRESSION AND TRANSCRIPTION FACTOR CBFA1 ON BONE-CELLS BY GLUCOCORTICOID, The Journal of biological chemistry, 273(9), 1998, pp. 4892-4896
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology
ISSN journal
0021-9258
Volume
273
Issue
9
Year of publication
1998
Pages
4892 - 4896
Database
ISI
SICI code
0021-9258(1998)273:9<4892:RITREA>2.0.ZU;2-H
Abstract
Glucocorticoid in excess suppresses bone formation in. vivo and disrup ts bone matrix protein synthesis by osteoblasts in vitro, In contrast, transforming growth factor beta (TGF-beta) potently enhances bone mat rix apposition. The rat TGF-beta type I receptor gene promoter contain s cis-acting elements for transcription factor CBFa1, which increases in parallel with osteoblast differentiation, Here we present molecular data linking these events. We show that previously unexplained effect s of glucocorticoid on bone loss may be mediated in part by suppressio n of CBFa1, with a resultant decrease in the expression and activity o f the TGF-beta type I receptor on matrix-producing bone cells.