POLYMORPHISM OF THE ANGIOTENSIN-I-CONVERTING-ENZYME GENE IN DIABETIC NEPHROPATHY IN TYPE-II DIABETIC-PATIENTS WITH PROLIFERATIVE RETINOPATHY

Citation
O. Hanyu et al., POLYMORPHISM OF THE ANGIOTENSIN-I-CONVERTING-ENZYME GENE IN DIABETIC NEPHROPATHY IN TYPE-II DIABETIC-PATIENTS WITH PROLIFERATIVE RETINOPATHY, Renal failure, 20(1), 1998, pp. 125-133
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
0886-022X
Volume
20
Issue
1
Year of publication
1998
Pages
125 - 133
Database
ISI
SICI code
0886-022X(1998)20:1<125:POTAGI>2.0.ZU;2-1
Abstract
Recently, deletion (D)/insertion (i) polymorphism in the Angiotensin I -converting enzyme (ACE) gene has been suggested to be related to the development of diabetic nephropathy in type I diabetes mellitus. This hypothesis, however, remains controversial. Differences in clinical st ates between patients, especially in glycemic control or duration of d iabetes, could be responsible for these contradictory results. In this study we examined the relationship between D/I polymorphism of the AC E gene and diabetic nephropathy in type II diabetic patients who had a lready developed proliferative retinopathy (n = 45), and were thought to have been in a hyperglycemic state for long enough to develop micro angiopathy. The patients were divided into two subgroups: 24 with neph ropathy (albumin excretion rate:AER greater than or equal to 20 mu g/m in) and 21 without (AER < 20 mu g/min). There was no difference in the duration of diabetes, HbAlc levels or average blood pressure over the previous year between these subgroups and other clinical characterist ics were comparable. Patients without nephropathy exhibited allele I m ore often than those with nephropathy (p = .025). AER was lowest in ge notype II and highest in genotype DD patients but the difference was n ot statistically significant (p = .07). From these findings, it was co ncluded that genotype II for the ACE gene could be a marker for reduce d risk of diabetic nephropathy.