HIV-1 SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION OF HUMAN AND NONHUMAN PRIMATE LYMPHOCYTES RESULTS IN THE MIGRATION OF CD2(-CELLS INTO THE INTESTINE OF ENGRAFTED SCID MICE() T)

Citation
Hh. Donze et al., HIV-1 SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION OF HUMAN AND NONHUMAN PRIMATE LYMPHOCYTES RESULTS IN THE MIGRATION OF CD2(-CELLS INTO THE INTESTINE OF ENGRAFTED SCID MICE() T), The Journal of immunology, 160(5), 1998, pp. 2506-2513
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
ISSN journal
0022-1767
Volume
160
Issue
5
Year of publication
1998
Pages
2506 - 2513
Database
ISI
SICI code
0022-1767(1998)160:5<2506:HSIVOH>2.0.ZU;2-#
Abstract
Increased lymphocytic infiltration of intestinal tissues has been obse rved in patients infected with HIV-1 and in SIV-infected rhesus macaqu es. To determine whether HIV-1 and SIV infections influence the homing of human and nonhuman primate PBMC to intestinal tissues, we engrafte d SCID mice with human or nonhuman primate PBMC and infected them with either cell-free or cell-associated HIV-1 or SIV, In mice that receiv ed both PBMC and virus, human or nonhuman primate CD2(+) T cells were found in intestinal tissues, primarily in the intraepithelial lymphocy te compartment and lamina propria, Immunomagnetic sorting revealed tha t these cells were derived from the CD4(+) population, Using gag-speci fic primers, PCR analysis of these tissues detected the presence of HI V-1 proviral DNA, However, in SCID mice that were engrafted with eithe r human or nonhuman primate PBMC and no HIV-1 or SIV, CD2(+) T cells w ere not detected in intestinal tissues, These results indicate that HI V-1 and SIV can modulate the migratory properties of human and nonhuma n primate T cells in the SCID mouse model.