MECHANISM OF ACUTE LUNG INJURY CAUSED BY INHALATION OF FABRIC PROTECTOR AND THE EFFECT OF SURFACTANT REPLACEMENT

Citation
K. Tashiro et al., MECHANISM OF ACUTE LUNG INJURY CAUSED BY INHALATION OF FABRIC PROTECTOR AND THE EFFECT OF SURFACTANT REPLACEMENT, Intensive care medicine, 24(1), 1998, pp. 55-60
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Emergency Medicine & Critical Care
Journal title
ISSN journal
0342-4642
Volume
24
Issue
1
Year of publication
1998
Pages
55 - 60
Database
ISI
SICI code
0342-4642(1998)24:1<55:MOALIC>2.0.ZU;2-5
Abstract
Objective: To evaluate the role of surfactant in the mechanism and tre atment of acute lung injury caused by inhalation of fabric protector. Design: Prospective, randomized study. Setting: University laboratory. Interventions: In vitro experiment: a porcine surfactant suspension ( 10 mg . ml(-1)) was exposed to a fabric protector aerosolized with an ultrasonic nebulizer for 1 min. Minimum surface tension (gamma min) wa s sequentially measured using pulsating bubble equipment. Animal exper iment: 14 adult rats were anesthetized with pentobarbital and mechanic ally ventilated with pure oxygen. Then, all rats inhaled fabric protec tor aerosolized with the nebulizer for five breaths. Three hours after inhalation, the rats were randomly assigned to two groups: a surfacta nt group (n = 7), in which surfactant (100 mg . kg(-1)) was replaced, and a control group (n = 7), in which no substance was given. Measurem ents and results: In vitro experiment: exposure to fabric protector ae rosol increased the mean gamma min of the surfactant from 1.7 to 19.2 mN . m(-1) (n = 5, p < 0.05). Animal experiment: the mean partial pres sure of oxygen in arterial blood (PaO2) in all rats decreased from 62. 8 to 17.1 kPa at 3 h after inhalation. The PaO2 in the surfactant grou p increased to 49.8 +/- 11.1 (SD) kPa at 30 min after surfactant repla cement (p < 0.05), while the PaO2 in the control group remained below 20 kPa. Conclusions: Impairment of surfactant is a factor involved in the development of acute lung injury caused by inhalation of fabric pr otector. Surfactant replacement may be therapeutic for such injuries.