THE EFFECTS OF UVB PLUS CALCIPOTRIOL ON SYSTEMIC CALCIUM HOMEOSTASIS IN PATIENTS WITH CHRONIC PLAQUE PSORIASIS

Citation
Jf. Bourke et al., THE EFFECTS OF UVB PLUS CALCIPOTRIOL ON SYSTEMIC CALCIUM HOMEOSTASIS IN PATIENTS WITH CHRONIC PLAQUE PSORIASIS, Clinical and experimental dermatology, 22(6), 1997, pp. 259-261
Citations number
6
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dermatology & Venereal Diseases
ISSN journal
0307-6938
Volume
22
Issue
6
Year of publication
1997
Pages
259 - 261
Database
ISI
SICI code
0307-6938(1997)22:6<259:TEOUPC>2.0.ZU;2-H
Abstract
We studied the effects of combining topical calcipotriol, used at the maximal licensed dose, and narrow-band short wave ultraviolet light (T LO1) on systemic calcium homeostasis in the treatment of chronic plaqu e psoriasis. Patients were randomized in an open fashion to receive ei ther UVB alone, UVB plus 100 g of calcipotriol (50 mu g/g) ointment pe r week or calcipotriol ointment alone (100 g/week). With the exception of a slight increase in serum phosphate in the group receiving combin ation therapy (from 0.92 to 1.22 mmol/l; P = 0.046), no differences we re observed between or within the groups. Psoriasis area and severity scores (PASI) improved to a greater extent in those patients receiving both UVB and calcipotriol (P=0.045). The combination of UVB and calci potriol is a safe, effective treatment for chronic plaque psoriasis.