ALLIIN AND VOLATILE SULFUR-CONTAINING-COMPOUNDS IN GARLIC ENHANCE THETHERMOGENESIS BY INCREASING NOREPINEPHRINE SECRETION IN RATS

Citation
Y. Oi et al., ALLIIN AND VOLATILE SULFUR-CONTAINING-COMPOUNDS IN GARLIC ENHANCE THETHERMOGENESIS BY INCREASING NOREPINEPHRINE SECRETION IN RATS, Journal of nutritional biochemistry, 9(2), 1998, pp. 60-66
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Nutrition & Dietetics",Biology
ISSN journal
0955-2863
Volume
9
Issue
2
Year of publication
1998
Pages
60 - 66
Database
ISI
SICI code
0955-2863(1998)9:2<60:AAVSIG>2.0.ZU;2-G
Abstract
The effects of alliin and volatile sulfur-containing compounds in garl ic on thermogenesis were investigated in rats. Rats were fed high-fat diet with or without a ethanol extracted-garlic powder (EE-garlic) sup plemented at 0.8% for 28 days. After feeding, mitochondrial protein co ntent in interscapular brown adipose tissue (IBAT) and plasma norepine phrine secretion were significantly greater in rats given EE-garlic as compared with control rats. The effects of the administrations of EE- garlic and alliin on norepinephrine secretions were evaluated in anest hetized rats. The norepinephrine concentrations of arterial blood were significantly increased by EE-garlic and alliin administration, and t hese increases were dose dependent. The administration of allylsulfide s having a different number of sulfur atoms (diallyldisulfide and dial lyltrisulfide) also significantly increased the norepinephrine secreti on. The effects of the administration of EE-garlic, alliin, and dially ldisulfide on thermogenesis were examined by the direct measurement of IBAT and rectal temperatures in anesthetized rats. The temperatures w ere significantly increased by the administration of these compounds, and the effect of diallyldisulfide disappeared in the presence of beta -adrenergic blocker. These results suggest that the administration of alliin and volatile sulfur-containing compounds in garlic enhance the thermogenesis by increasing norepinephrine secretion via beta-adrenerg ic action. (C) Elsevier Science Inc. 1998.