DECREASED EXPRESSION OF MLH1, MSH2, PMS1 AND PMS2 IN PIGMENTED LESIONS INDICATES ACCUMULATION OF FAILED DNA-REPAIR ALONG WITH MALIGNANT TRANSFORMATION AND TUMOR PROGRESSION

Citation
M. Korabiowska et al., DECREASED EXPRESSION OF MLH1, MSH2, PMS1 AND PMS2 IN PIGMENTED LESIONS INDICATES ACCUMULATION OF FAILED DNA-REPAIR ALONG WITH MALIGNANT TRANSFORMATION AND TUMOR PROGRESSION, Oncology Reports, 4(3), 1997, pp. 653-655
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ISSN journal
1021-335X
Volume
4
Issue
3
Year of publication
1997
Pages
653 - 655
Database
ISI
SICI code
1021-335X(1997)4:3<653:DEOMMP>2.0.ZU;2-T
Abstract
The tumorigenesis of human nonpolyposis colorectal cancer was reported to be connected with the mutations in DNA mismatch repair genes. The main aim of this study was to check the epression of 4 proteins MLH1, MSH2, PMS1 and PMS2 responsible for mismatch DNA repair in naevi and m elanomas. Fifty-one naevi, 78 primary melanomas, 30 lymphatic and 7 or gan melanoma metastases were stained for the presence of MLH1, MSH2, P MS1 and PMS2. All proteins were preserved in 88% of naevi and only in 37% of primary melanomas, 17% of lymphatic metastases and in none of t he distant metastases. The difference of expression of all 4 proteins between naevi and melanomas was highly significant (p<0.01). MLH1 and MSH2 correlated significantly with each other as well with the follow- up of patients. On the basis of our results one can conclude that the defect of mismatch DNA repair plays an important role in both tumorige nesis of melanoma and metastatic spread of tumour.