HEPATOBILIARY ALTERATIONS IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE- A MULTICENTER STUDY

Citation
G. Riegler et al., HEPATOBILIARY ALTERATIONS IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE- A MULTICENTER STUDY, Scandinavian journal of gastroenterology, 33(1), 1998, pp. 93-98
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
0036-5521
Volume
33
Issue
1
Year of publication
1998
Pages
93 - 98
Database
ISI
SICI code
0036-5521(1998)33:1<93:HAIPWI>2.0.ZU;2-1
Abstract
Background and Methods: Four hundred and eighty-four patients with inf lammatory bowel disease underwent clinical examination, ultrasonograph y, and biochemical liver function tests, to estimate the prevalence of hepatobiliary alterations. The patient group included patients withou t a history of liver disease. Controls were recruited from patients wi th functional symptoms. Results: More patients with ulcerative colitis than controls had liver steatosis and increased alkaline phosphatase levels. Factors increasing the probability of liver damage were long-s tanding disease, the presence of moderate/severe disease activity, and treatment with steroids and mesalazine. A significant association was found between biliary disease and long-standing colitis and also ther apy with steroids and mesalazine. Alkaline phosphatase and aminotransf erase levels were significantly higher in Crohn's disease patients tha n in controls. Hepatic and biliary damage was found more commonly in t he Ist year after diagnosis. Conclusions: The monitoring of hepatobili ary function is suggested for patients with inflammatory bowel disease , even in the absence of symptoms and history.