PERIODONTITIS AND CONCENTRATIONS OF THE CELLULAR IMMUNE ACTIVATION MARKER NEOPTERIN IN SALIVA AND URINE

Citation
K. Vrecko et al., PERIODONTITIS AND CONCENTRATIONS OF THE CELLULAR IMMUNE ACTIVATION MARKER NEOPTERIN IN SALIVA AND URINE, Clinica chimica acta, 268(1-2), 1997, pp. 31-40
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Laboratory Technology",Biology
Journal title
ISSN journal
0009-8981
Volume
268
Issue
1-2
Year of publication
1997
Pages
31 - 40
Database
ISI
SICI code
0009-8981(1997)268:1-2<31:PACOTC>2.0.ZU;2-U
Abstract
Neopterin concentrations in diverse body fluids provide a well establi shed indication for activation of the cell-mediated immune system. Neo pterin concentrations were measured in the saliva and urine of 29 pati ents with varying numbers of teeth affected by periodontitis. While ne opterin concentrations in urine increased slightly but not significant ly in parallel with increasing numbers of affected teeth, salivary neo pterin levels showed a significant and positive correlation with numbe r of diseased teeth (linear correlation coefficient = 0.48, P = 0.012) . Additionally, when the patients were grouped according to the median number of affected teeth (20), salivary specimens of subjects with on e to 20 affected teeth showed significantly lower neopterin concentrat ions than specimens from those with more than 20 diseased teeth (P = 0 .0045, Student's t-test). In contrast, urinary neopterin concentration s did not differ significantly among these two groups. This pilot stud y suggests that salivary neopterin concentrations may reflect local im mune activation even in situations where no systemic activation can be detected. (C) 1997 Elsevier Science B.V.